Kuby Immunology 8th Edition By Jenni Punt, Sharon Stranford, Patricia Jones, Judith Owen

Adaptive Immunity: Antigen Receptors & MHC Adaptive Immunity: Effector Responses Allergy Hypersensitivities and Chronic Inflammation antibody-based assays (ELISA Western Blot) B-Cell Activation Differentiation and Memory Generation B-Cell Development – Bone marrow maturation steps allelic exclusion and central tolerance mechanisms Barrier Immunity: The Immunology of Mucosa and Skin Cancer and the Immune System – Tumor antigens immune evasion by tumors and modern cancer immunotherapies Cells Organs and Microenvironments of the Immune System – Primary and secondary lymphoid organs Costimulation Th1/Th2/Th17/Treg differentiation and immunological memory generation Dynamic trafficking lymphocyte homing and the spatiotemporal coordination of real-time immune responses Effector Responses: Antibody- and Cell-Mediated Immunity flow cytometry and transgenic animal models germinal center reactions somatic hypermutation and class-switch recombination Immunodeficiency Diseases – Primary (genetic) immunodeficiencies (e.g. SCID) and secondary (acquired) immunodeficiencies (e.g. HIV/AIDS) Infectious Diseases and Vaccines – Immune responses to viruses bacteria fungi and parasites Innate Immunity ISBN-13: 978-1319114701 ISBN-13: 978-1319172985 ISBN-13: 978-1319498658 ISBN-13: 978-1464189784 Mechanisms of cell-to-cell signaling ligand-receptor interactions and intracellular cascades MHC Class I and II properties processing pathways and presentation to T cells Neutralization opsonization ADCC and cytotoxic T lymphocyte (CTL) / Natural Killer (NK) cell functions Pattern recognition receptors (PRRs) phagocytosis anatomical barriers and early induced responses T-Cell Activation Helper Subset Differentiation and Memory T-Cell Development – Thymic selection positive and negative selection and lineage commitment T-dependent and T-independent activation The Adaptive Immune Response in Space and Time The Complement System –lectin pathways regulatory mechanisms and biological consequences of complement activation The Immune System in Health & Disease the Immune System – Introduction to innate vs. adaptive immunity clonal selection The Major Histocompatibility Complex and Antigen Presentation The Organization and Expression of Lymphocyte Receptor Genes Tolerance Autoimmunity and Transplantation Types I–IV hypersensitivities systemic anaphylaxis and chronic inflammatory disorders V(D)J recombination genetic diversity of B-cell receptors (BCRs) and T-cell receptors (TCRs)