Introduction to Genetic Analysis 12th Edition By Anthony Griffiths, John Doebley, Catherine Peichel, David Wassarman
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- Analytical Chemistry
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About this ebook
The 12th edition of Introduction to Genetic Analysis by Anthony Griffiths, John Doebley, Catherine Peichel, and David A. Wassarman structures the study of genetics into three primary segments: Transmission Genetics, Molecular Genetics, and Evolutionary Genetics. [1, 2]
The textbook covers the following core topics across its 20 chapters: [1]
Transmission (Mendelian) Genetics
- Introduction to the Field: The Genetics Revolution in the Life Sciences.
- Single-Gene Inheritance: Monohybrid crosses, phenotypic ratios, and Mendelian pedigree analysis.
- Independent Assortment of Genes: Dihybrid/multihybrid crosses and the chromosomal basis of independent assortment.
- Chromosome Mapping: Mapping eukaryote chromosomes by recombination and linkage analysis.
- Gene Interaction: How multiple genes interact to determine a single phenotypic trait (epistasis, penetrance, expressivity).
- Microbial Genetics: The genetics of bacteria and their viruses (conjugation, transformation, transduction). [1, 2]
Molecular Genetics
- DNA Structure and Replication: The physical chemistry of the double helix and the mechanism of DNA replication.
- Gene Expression: RNA transcription, mRNA processing, modification, decay, and protein translation/synthesis.
- Gene Isolation and Manipulation: Recombinant DNA technology, PCR, and modern genetic tools like CRISPR-Cas9.
- Regulation of Gene Expression: Transcriptional control in prokaryotes (operons) as well as chromatin-mediated and eukaryotic transcriptional regulation.
- Developmental Genetics: The genetic control of development and pattern formation in model organisms.
- Genomics: Whole-genome sequencing, structural genomics, and functional genomics. [1, 2]
Genome Dynamics & Variation
- DNA Mutation and Repair: Mechanisms of gene mutation, cellular pathways for DNA repair, and homologous recombination.
- The Dynamic Genome: Transposable elements (transposons) and their role in genome evolution.
- Chromosomal Changes: Large-scale chromosomal mutations, including changes in chromosome structure (inversions, translocations) and number (polyploidy, aneuploidy). [1]
Evolutionary & Quantitative Genetics
- Population Genetics: Allele and genotype frequencies, the Hardy-Weinberg equilibrium, and forces altering allele frequencies (selection, mutation, drift, migration).
- Complex Traits: The inheritance of quantitative and multifactorial traits controlled by multiple genes and environmental factors.
- Evolutionary Genetics: Evolution of genes, traits, and species over time using molecular systematics. [1, 2]
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