Fundamentals of Drug Delivery By Heather Benson, Michael Roberts, Adrian Williams, Xiaowen Liang
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- 565
- File size
- 13.5 MB
- Format
- Digital PDF
- Course
- Education
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- eBook[PDF]
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About this ebook
Fundamentals of Drug Delivery, edited by Heather A.E. Benson, Michael S. Roberts, Adrian C. Williams, and Xiaowen Liang, is a comprehensive textbook divided into three core parts. It covers everything from basic physiological barriers to advanced nanotechnologies used in modern controlled drug delivery systems. [1, 2, 3]
The primary topics covered across its three sections include:
Part 1: Introduction, Challenges, and Fundamental Processes
This foundational section introduces the core concepts of drug development and the pharmacokinetic factors influencing drug behavior. [1, 2]
- Drug development stages: Selecting pharmaceutical candidates and evaluating their unique physicochemical properties.
- Pharmacokinetics: The impact and role of drug transporters on how drugs are distributed and disposed of by the body.
- Mathematical modeling: Utilizing mathematical simulations to model, predict, and analyze drug disposition and release profiles.
- General overview: Introduction to modern controlled delivery innovations, opportunities, and historical perspectives. [1, 2]
Part 2: Common Administration Routes & Physiological Barriers
This section provides a detailed "top to bottom" review of how drugs are delivered through specific pathways, focusing heavily on anatomy, physiology, and tissue barriers. [1, 2]
- Oral and Parenteral routes: Delivery mechanisms via oral ingestion, as well as intravenous (IV), intramuscular (IM), and subcutaneous (SC) injections.
- Dermal & Transdermal routes: Overcoming the skin barrier to administer therapies locally or systematically.
- Pulmonary & Nasal routes: Delivering medications efficiently through the lungs and nasal pathways.
- Ocular, Ear, and Mucosal routes: Specialized targeting mechanisms through the eyes (ocular), ears (otic), and other mucosal tissues. [1, 2, 3]
Part 3: Advanced Technologies and Future Horizons
The final portion summarizes cutting-edge engineering and formulation breakthroughs shaping the future of therapeutics. [1, 2]
- Nanotechnology: Application of nanomaterials, specifically focusing on dermal delivery systems.
- Biologics delivery: Formulating advanced systems tailored specifically for complex biological drugs and proteins.
- Targeted and cell-mediated delivery: Mechanisms designed to safely guide drugs to specific disease sites while addressing toxicological and safety limitations. [1, 2]
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