eBook BONE AND JOINT INFECTIONS from microbiology to diagnostics and treatment. 2nd Edition By Werner Zimmerli
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- Pages
- 467
- File size
- 16.48 MB
- Format
- Digital PDF
- Course
- Microbiology
- Category
- eBook[PDF]
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About this ebook
The second edition of Bone and Joint Infections: From Microbiology to Diagnostics and Treatment by Werner Zimmerli covers a broad, updated scope of both non-implant and implant-associated orthopedic infections. [1]
The textbook is divided into structured clinical areas focusing on pathogen microbiology, advanced diagnostic approaches, and combined surgical-antimicrobial therapeutic strategies. [1, 2]
Major Core Topics Covered
- Pathogenesis and Biofilm Infections: Detailed coverage of how microorganisms adhere to non-living surfaces like dead bone (sequestra) and hardware implants to form complex biofilms. [1]
- Non-Implant Orthopedic Infections: Clinical evaluation and management of native-tissue conditions including osteomyelitis, septic/native arthritis, and spinal infections (vertebral osteomyelitis/discitis). [1, 2]
- Implant-Associated Infections: Deep clinical workflows for managing infections linked to bone fixation devices and periprosthetic joint infections (PJI). [1]
- Imaging Interpretation: Guidance for clinicians on interpreting specialized radiological studies, particularly MRI-based images, to rapidly plan comprehensive therapy. [1]
New and Updated Content in the 2nd Edition
The revised second edition expands heavily on molecular tools and modern therapeutic technologies via four brand-new chapters and updated laboratory diagnostics: [1]
- Advanced Diagnostics Approach: Systematic diagnostic pipelines explicitly outlined for distinct joint, spine, and hardware environments.
- Non-Culture Pathogen Identification: Focus on modern molecular methods such as eubacterial PCR, multiplex PCR, and shotgun metagenomics to identify fastidious pathogens and increase the fraction of culture-negative cases solved.
- Unusual Microorganisms in PJIs: Specific guidance on handling rare or difficult-to-isolate pathogens in prosthetic joints, including specific Gram-positive strains (Staphylococcus lugdunensis, Listeria, Nocardia), Gram-negative bacteria (Salmonella, Neisseria), and zoonotic pathogens (Brucella, Francisella).
- Bacteriophage Therapy: Emerging management strategies for multi-resistant bacterial strains using phages. [1, 2]
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16.48 MB
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