Cellular and Molecular Immunology 11th Edition By Abul Abbas, Andrew Lichtman, Shiv Pillai, Sarah Henrickson
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- 668
- File size
- 13.13 MB
- Format
- Digital PDF
- Course
- Clinical Medicine
- Category
- eBook[PDF]
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About this ebook
The 11th edition of Cellular and Molecular Immunology by Abul K. Abbas, Andrew H. Lichtman, and Shiv Pillai (with new co-author Sarah Henrickson) covers 21 chapters. The topics span the fundamental principles of basic immunology to the mechanisms of clinical immunologic diseases. [1, 2]
The specific chapter topics covered in this edition include:
Introduction and System Architecture
- Overview of the Immune System: Core principles and properties of immune responses.
- Cells and Tissues of the Immune System: Anatomical structures, primary and secondary lymphoid organs.
- Leukocyte Circulation and Migration into Tissues: How immune cells travel throughout the body to sites of infection. [1, 2]
Innate Responses and Antigen Recognition
- Innate Immunity: The body's immediate, non-specific defense mechanisms and pathogen recognition.
- Antibodies and Antigens: Structural properties of immunoglobulins and how they bind to foreign targets.
- Antigen Presentation to T Lymphocytes: The role of Major Histocompatibility Complex (MHC) molecules in displaying antigens. [1]
Receptor Signaling and Lymphocyte Development
- Immune Receptors and Signal Transduction: The molecular pathways that trigger cellular action upon antigen binding.
- Lymphocyte Development and Antigen Receptor Gene Rearrangement: The genetic processes behind T and B cell maturation and receptor diversity. [1]
T Cell-Mediated Immunity
- Activation and Regulation of T Lymphocytes: Early events in T cell activation and control mechanisms.
- Differentiation and Functions of CD4+ Effector T Cells: Helper T cell subsets (such as Th1, Th2, and Th17) and their specific roles.
- Differentiation and Functions of CD8+ Effector T Cells: Cytotoxic T cell mechanisms used to kill infected or mutated cells. [1]
Humoral Immunity and Barrier Defense
- B-Cell Activation and Antibody Production: The stimulation of B cells and subsequent antibody manufacturing.
- Effector Mechanisms of Humoral Immunity: How antibodies neutralize and eliminate pathogens (e.g., complement system, opsonization).
- Specialized Immunity at Epithelial Barriers and in Immune-Privileged Tissues: Mucosal immunity, skin defense networks, and restricted locations like the brain or eyes. [1]
Immune Regulation and Pathology
- Immunologic Tolerance and Autoimmunity: Mechanisms preventing the body from attacking itself and what happens when they fail.
- Immunity to Microbes: Targeted defense strategies against bacteria, viruses, fungi, and parasites.
- Transplantation Immunology: The immune barriers to organ and tissue grafts.
- Tumor Immunology: The body's response to cancer cells and modern immunotherapy principles.
- Hypersensitivity Disorders: Unwanted immune reactions causing tissue injury.
- Allergy: IgE-mediated immune responses and mast cell triggers.
- Congenital and Acquired Immunodeficiencies: Primary genetic immune failures alongside acquired disorders such as HIV/AIDS. [1]
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