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Basic to Modern Strategies of Synthetic Organic Chemistry 1st Edition By Hyun-Joon Ha

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248
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15.14 MB
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About this ebook
The 1st edition of Basic to Modern Strategies of Synthetic Organic Chemistry by Hyun-Joon Ha (published by Elsevier) bridges foundational organic reactions with advanced, contemporary methodologies. [1, 2]
The book is structured into 9 core chapters: [1]
1. Overview of Organic Synthesis
  • Introduction to molecular engineering.
  • Core principles of building chemical frameworks. [1]
2. Fundamentals of Organic Chemistry Reactions
  • Key reactive intermediates: carbocations, carbanions, radicals, and carbenes.
  • Substitution (\(S_{N}1\), \(S_{N}2\)) and elimination (E1, E2) kinetics and mechanisms.
  • Carbonyl chemistry, including enolate formation and nucleophilic additions.
  • Classical condensation reactions (e.g., Aldol, Claisen) and umpolung techniques. [1, 2]
3. Oxidation-Reduction Reactions
  • Mechanisms of selective functional group oxidations (e.g., aldehydes to carboxylic acids).
  • Chemoselective reductions using metal hydrides (NaBH₄, LiAlH₄) and related reagents. [1]
4. Pericyclic Reactions and Cyclization
  • Mechanism-driven ring-closing transformations.
  • Orbital symmetry and stereochemical outcomes in concerted reactions.
5. Reaction Selectivity, Protecting Groups, and Stereoselectivity
  • Regioselectivity and stereoselectivity controls in multi-step pathways.
  • Strategic use of protecting groups to shield vulnerable functional clusters.
  • Asymmetric synthesis methodologies for preparing chiral molecules. [1, 2, 3, 4]
6. Synthetic Strategies and Retrosynthesis
  • Logic-based retrosynthetic analysis and bond disconnections.
  • Transition-metal-catalyzed cross-coupling mechanisms (e.g., Suzuki, Heck) and olefin metathesis. [1, 2]
7. Environmentally Friendly Organic Synthesis and Catalytic Reactions
  • Application of organocatalysis and green chemistry metrics.
  • Reducing environmental and economic impacts in pharmaceutical and fine chemical manufacturing. [1, 2]
8. Flow Technology in Organic Synthesis
  • Introduction to continuous flow chemistry.
  • Engineering concepts, automated microreactors, and scaling up laboratory reactions. [1]
9. Examples of Total Synthesis
  • Real-world case studies detailing the complete assembly of complex target molecules.
  • Practical tips, handles, and tricks to bypass typical troubleshooting traps.

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Topics

Application of organocatalysis and green chemistry metrics Asymmetric synthesis methodologies for preparing chiral molecules Carbonyl chemistry including enolate formation and nucleophilic additions Chemoselective reductions using metal hydrides (NaBH₄ LiAlH₄) and related reagents Classical condensation reactions (e.g. Aldol Claisen) and umpolung techniques Engineering concepts automated microreactors and scaling up laboratory reactions Environmentally Friendly Organic Synthesis and Catalytic Reactions Flow Technology in Organic Synthesis functional group oxidations (e.g. aldehydes to carboxylic acids) Fundamentals of Organic Chemistry Reactions Introduction to continuous flow chemistry ISBN-10: 044333126X ISBN-10: 0443331278 ISBN-13: 978-0443331268 ISBN-13: 978-0443331275 Key reactive intermediates: carbocations carbanions radicals and carbenes Logic-based retrosynthetic analysis and bond disconnections Mechanism-driven ring-closing transformations Orbital symmetry and stereochemical outcomes in concerted reactions Organic Synthesis Introduction to molecular engineering. Oxidation-Reduction Reactions Pericyclic Reactions and Cyclization Reaction Selectivity Protecting Groups and Stereoselectivity Reducing environmental and economic impacts in pharmaceutical and fine chemical manufacturing Regioselectivity and stereoselectivity controls in multi-step pathways Substitution (\(S_{N}1\) \(S_{N}2\)) and elimination (E1 E2) kinetics and mechanisms Synthetic Strategies and Retrosynthesis Transition-metal-catalyzed cross-coupling mechanisms (e.g. Suzuki Heck) and olefin metathesis