Basic to Modern Strategies of Synthetic Organic Chemistry 1st Edition By Hyun-Joon Ha
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- Pages
- 248
- File size
- 15.14 MB
- Format
- Digital PDF
- Course
- Chemistry
- Category
- eBook[PDF]
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About this ebook
The 1st edition of Basic to Modern Strategies of Synthetic Organic Chemistry by Hyun-Joon Ha (published by Elsevier) bridges foundational organic reactions with advanced, contemporary methodologies. [1, 2]
The book is structured into 9 core chapters: [1]
1. Overview of Organic Synthesis
- Introduction to molecular engineering.
- Core principles of building chemical frameworks. [1]
2. Fundamentals of Organic Chemistry Reactions
- Key reactive intermediates: carbocations, carbanions, radicals, and carbenes.
- Substitution (\(S_{N}1\), \(S_{N}2\)) and elimination (E1, E2) kinetics and mechanisms.
- Carbonyl chemistry, including enolate formation and nucleophilic additions.
- Classical condensation reactions (e.g., Aldol, Claisen) and umpolung techniques. [1, 2]
3. Oxidation-Reduction Reactions
- Mechanisms of selective functional group oxidations (e.g., aldehydes to carboxylic acids).
- Chemoselective reductions using metal hydrides (NaBH₄, LiAlH₄) and related reagents. [1]
4. Pericyclic Reactions and Cyclization
- Mechanism-driven ring-closing transformations.
- Orbital symmetry and stereochemical outcomes in concerted reactions.
5. Reaction Selectivity, Protecting Groups, and Stereoselectivity
- Regioselectivity and stereoselectivity controls in multi-step pathways.
- Strategic use of protecting groups to shield vulnerable functional clusters.
- Asymmetric synthesis methodologies for preparing chiral molecules. [1, 2, 3, 4]
6. Synthetic Strategies and Retrosynthesis
- Logic-based retrosynthetic analysis and bond disconnections.
- Transition-metal-catalyzed cross-coupling mechanisms (e.g., Suzuki, Heck) and olefin metathesis. [1, 2]
7. Environmentally Friendly Organic Synthesis and Catalytic Reactions
- Application of organocatalysis and green chemistry metrics.
- Reducing environmental and economic impacts in pharmaceutical and fine chemical manufacturing. [1, 2]
8. Flow Technology in Organic Synthesis
- Introduction to continuous flow chemistry.
- Engineering concepts, automated microreactors, and scaling up laboratory reactions. [1]
9. Examples of Total Synthesis
- Real-world case studies detailing the complete assembly of complex target molecules.
- Practical tips, handles, and tricks to bypass typical troubleshooting traps.
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