Clinical, Biological and Molecular Aspects of COVID-19 (Advances in Experimental Medicine and Biology, 1321) 1st ed. 2021 Edition
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- 356
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- 9.01 MB
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- Medical Studies
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- eBook[PDF]
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About this ebook
The Clinical, Biological and Molecular Aspects of COVID-19 (Advances in Experimental Medicine and Biology, Volume 1321), edited by Paul C. Guest and published by Springer in 2021, provides an early pandemic-era analysis of SARS-CoV-2. [1, 2]
The volume features contributions from leading international experts across clinical medicine, virology, and molecular biology. The major topics covered in the book are organized into three primary thematic domains: [1]
1. Molecular & Biological Pathogenesis
- Viral Structure and Lifecycle: Comprehensive analysis of the basic molecular biology, structural properties, genomic characterization, and replication machinery of SARS-CoV-2. [1, 2]
- Receptor Interaction & Entry Mechanisms: Focus on how the virus binds to human host cells, predominantly focusing on the ACE2 receptor and TMPRSS2 protease. [1]
- The Inflammatory Response: Detailed review of virus-induced inflammation, the "cytokine storm" disorder, hyper-inflammation, and the systemic biological pathways leading to severe tissue damage. [1, 2]
- Endothelial and Vascular Dysfunction: Explores how COVID-19 acts as an endothelial disease, looking specifically at the role of nitric oxide deficiency and endothelial protection. [1]
- Cellular Models: Methodologies regarding peripheral blood mononuclear cells (PBMCs) to monitor mitochondrial dysfunction and cellular viability during infectious inflammatory states. [1]
2. Clinical Manifestations & Epidemiology
- Comorbidities and High-Risk Groups: Deep dives into how the virus affects vulnerable populations, specifically older adults and individuals with pre-existing metabolic conditions such as diabetes, heart disease, and asthma. [1]
- Primary Outcomes & Patient Features: Documentation of raw clinical data, hospitalization times, mortality risk factors, and common presentation symptoms (e.g., dyspnea, fever, cough, and elevated blood urea nitrogen). [1]
- Systemic Complications: Early tracking of multi-organ impacts, including respiratory failure, Acute Respiratory Distress Syndrome (ARDS), and microembolic or thrombotic disorders. [1]
- Neurological & Cerebrovascular Impacts: Case-based systematic reviews highlighting acute cerebrovascular events like ischemic strokes and the methods by which the virus breaks through the blood-brain barrier (BBB). [1, 2]
3. Therapeutics, Preventative Strategies & Psychosocial Effects
- Psychological & Mental Health Burdens: Cross-sectional survey evaluations assessing the prevalence of severe anxiety, depression, and stress among hospitalized COVID-19 patients and healthcare staff.
- Early Vaccine Approaches: Reviews of early pipeline developments, including mRNA, DNA, viral vector, and subunit vaccines, alongside the molecular frameworks required to elicit successful immunological memory.
- Targeted Pharmacotherapies: Analysis of prospective medical therapies, including early data on the effectiveness of anti-inflammatory corticosteroids and endothelial-protective drugs like statins. [1, 2, 3, 4, 5, 6]
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