Human Evolutionary Genetics 3rd Edition By Mark Jobling, Edward Hollox
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- Education
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About this ebook
The third edition of Human Evolutionary Genetics (published by CRC Press) expands significantly on earlier versions by integrating modern and ancient whole-genome sequencing data. Written by Mark Jobling, Edward Hollox, Brenna Henn, Toomas Kivisild, Luca Pagani, and Chris Tyler-Smith, the textbook bridges molecular genetics with paleontology, archaeology, paleoclimatology, and linguistics. [1, 2]
The text covers several core thematic areas and topics:
1. Foundations of Genome Variation & Evolution
- Genome Variation & Diversity: Mechanisms of mutation, structural variants, and the scale of diversity in present-day human populations.
- Demography & Population History: Using genetic variation to reconstruct past population sizes, migrations, bottlenecks, and expansions.
- Evolutionary Selection: Identifying signals of natural selection (positive, negative, and balancing selection) within the human genome. [1, 2]
2. Deep Prehistoric Origins & Archaic Humans
- Prehistoric Origins: A genetic journey tracking the origins of early human ancestors. [1]
- Archaic Hominins: Insights from ancient DNA regarding Neanderthals, Denisovans, and early Homo sapiens, including archaic admixture and interbreeding events. [1]
- Historical Eras: Exploring how human movements, agriculture, and empires shaped regional genetic landscapes up to the historical period. [1]
3. Functional and Phenotypic Consequences
- Genetic Disorders: The evolutionary context of hereditary diseases and why certain deleterious variants persist in populations. [1, 2]
- Infectious Disease Susceptibility: How past epidemics and pathogens have acted as selective pressures, shaping the evolution of the human immune system. [1, 2]
- Normal Phenotypic Variation: The genetics behind complex physical traits, adaptations to diverse environments (e.g., altitude, diet, climate), and pigmentation. [1, 2]
4. Co-evolution & Modern Applications
- Inter-species Evolutionary Dynamics (New Chapter): The roles of domesticated animals, internal parasites, and the human microbiome in the broader story of human evolution.
- The Personal Genome: The technology, accuracy, and rise of direct-to-consumer (DTC) genetic testing.
- Societal & Future Horizons: Social and cultural influences on genetic diversity, ethical issues surrounding genetic tracking, and the ongoing trajectory of human evolution. [1, 2]
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